When excessive energy is ingested, WAT stores energy in the form of triglycerides in unilocular white adipocytes, and it secretes many adipokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and plasminogen activator inhibitor-1 (PAI-1), which induce insulin resistance [1, 2]. This evidence concerns the gene SERPINE1 and Insulin resistance.