EGFR and neoplasm: In 2016, Xin et al. [27] developed a new tumor-targeting MRI contrast agent by conjugating gadolinium-diethylene triamine pentaacetate (Gd-DTPA) to the bispecific recombinant anti-EGFR-iRGD protein (anti-EGFR-iRGD-DTPA-Gd).