CREBBP and breast cancer: Previous studies have proved that BMAL1 can strengthen p65 through recruiting CBP acetylation and activation of NF-κB [46], the CoIP assay found that BMAL1 can interact with CBP, overexpression of BMAL1 can increase the BMAL1-p65 compound CBP in abundance, as a result, BMAL1 can increase the recruitment of CBP to enhance p65 activity, and further enhance the expression of MMP9 target genes, promote the invasion and metastasis of breast cancer cells.