Among of them, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) due to degradation of ECM IV type collagen, the primary components of the basement membrane damaged prompted local invasion and distant metastasis and have the closest relations with invasion and metastasis of tumor [29, 30], real-time quantitative PCR assay and Western blot assay were used to detect the changes of MMP2 and MMP9 when overexpressed BMAL1. The gene discussed is MMP2; the disease is neoplasm.