It was indicated from the functional enrichment results that the genes involved in the screened modules of the networks for miR-29a and miR-29b both played important roles in several signaling pathways associated with the occurrence and development of CRC such as pathways in cancer, PI3K-Akt signaling pathway, p53 signaling pathway, microRNAs in cancer, cell cycle, FoxO signaling pathway, proteoglycans in cancer, HIF-1 signaling pathway and colorectal cancer. The gene discussed is TP53; the disease is colorectal cancer.