The results indicated that the genes targeted by miR-29a and miR-29b were enriched into similar pathways strongly associated with CRC initiation and development, such as pathways in cancer, PI3K-Akt signaling pathway, p53 signaling pathway, cell cycle, colorectal cancer and FoxO signaling pathway and microRNAs in cancer. The gene discussed is TP53; the disease is colorectal cancer.