Through PPI network construction, several key hub genes regulated by miR-29a and miR-29b were identified and both enriched into a series of CRC related signaling pathways including pathways in cancer, PI3K-Akt signaling pathway, microRNAs in cancer, colorectal cancer and proteoglycans in cancer, HIF-1 signaling pathway, and VEGF signaling pathway. This evidence concerns the gene VEGFA and colorectal cancer.