To summarise this study, in vitro and in vivo data collectively showed that DNA gyrase activity was strongly correlated with the growth of Mle. Importantly, immersion in hot springs or saunas, whose temperatures are typically above 40 °C, may effectively treat or prevent leprosy because the enzyme is inactive and the bacilli grow poorly at temperatures higher than 37 °C. The gene discussed is TOP2A; the disease is leprosy.