Notably, after controlling for APOE genotypes (both APOE-ε4 and APOE-ε2), PVRL2 haplotype alpha, APOC1 haplotype gamma, and the two APOE-ε4–harboring extended haplotypes (delta and epsilon) still manifested as conferring a significantly elevated risk for AD (Supplementary Tables 11, 12). This evidence concerns the gene APOE and Alzheimer disease.