APOE and Alzheimer disease: Accordingly, multiple AD-associated variants from the PVRL2 and APOC1 loci with p-values < 5 × 10−8 were identified in APOE-ε4 carriers (n = 12,738 and 13,850 for AD and NC carrying APOE-ε4, respectively; Supplementary Table 2) and in all individuals after adjusting for APOE-ε4 genotype (n = 21,392 and 38,164 for AD and NC, respectively; Supplementary Table 3).