To further investigate the existence of additional risk signals in this region, we conducted fine-mapping analysis in the extended APOE region (chr19:45,300,000–45,500,000) using the GATK HaplotypeCaller, which enables the simultaneous detection of SNPs and INDELs in the WGS data of this cohort and an AD cohort from Hong Kong. This evidence concerns the gene APOE and Alzheimer disease.