APOE and Alzheimer disease: To further dissect the AD-associated genetic structure in APOE and the surrounding region, we included additional variants (i.e., SNPs and INDELs) that were in LD (r2 ≥ 0.50) with the nine causal variants in mainland Chinese WGS dataset, which yielded 33 variants that might reflect the AD-associated genetic signatures in this region (Supplementary Table 4).