Our haplotype analysis identified PVRL2 and APOC1 minor haplotypes that exhibit independent risk effects for AD in parallel with APOE-ε4, as well as long-range AD risk haplotypes defined by the combination of PVLR2, APOE, and APOC1 risk haplotypes that exhibit stronger risk effects than APOE-ε4 alone. Here, APOE is linked to Alzheimer disease.