In addition, we confirmed the existence of the minor haplotypes in PVRL2 and APOC1 loci (PVRL2 haplotype alpha, PVRL2 haplotype beta, and APOC1 haplotype gamma), as well as APOE-ε4–harboring extended haplotypes (haplotypes delta and epsilon; Fig. 2c) defined by the combination of PVRL2, APOE, and APOC1 minor haplotypes in non-Asian populations (predominantly Caucasian populations using three array-based AD genetic datasets, ADC, LOAD, and ADNI; Supplementary Tables 1, 8). This evidence concerns the gene APOE and Alzheimer disease.