APOE and Alzheimer disease: Using a partial correlation test controlling for confounding factors, we confirmed that there were more frequent associations between PVRL2 haplotype alpha and APOC1 haplotype gamma or APOE-ε4 in the AD and MCI groups when compared to the control groups (Fig. 2c–e; Supplementary Table 5); we validated these findings in the ADNI WGS and Hong Kong Chinese WGS cohorts (Supplementary Tables 1, 6, 7).