Moreover, upon the D-bLP-mediated TSM remodeling, the second delivered DiI/M-bLP would exceedingly permeate from tumor vessel into the distal matrix and efficiently reach the 4T1-GFP cell regions in tumor, ultimately producing a 27.0-fold increase of second DiI/M-bLP accessibility in 4T1-GFP cell regions (Supplementary Fig. 20). Here, DYNLRB1 is linked to neoplasm.