In this work, although the small-sized bioinspired lipoproteins of D-bLP, DM-bLP, and DiI/M-bLP can considerably accumulate in tumor and penetrate the tumor mass (Figs. 3, 5; Supplementary Fig. 16), they are largely hijacked by stromal cells and unable to reach the cancer cells in tumor (Figs. 3, 7; Supplementary Figs. 5–7). The gene discussed is DYNLRB1; the disease is cancer.