Accordingly, we here design a bioinspired lipoprotein (bLP) nanosystem that, respectively, loads photothermal agent of DiOC18(7) (DiR) (termed as D-bLP) and anticancer drug of mertansine (termed as M-bLP), aiming at remodeling TSM barriers with D-bLP-mediated photothermia and augmenting the accessibility of second-wave M-bLP to cancer cells in tumor for efficient suppression of tumor relapse and metastasis (Fig. 1). The gene discussed is DYNLRB1; the disease is cancer.