Importantly, using the median or upper quartile of JMJD6 mRNA expression as the cut-off points, multivariable Cox regression analysis showed that high levels of JMJD6 mRNA expression was associated with poor patient overall survival and event-free survival, independent of disease stage, age at the time of diagnosis and MYCN amplification status (Table 1), and the current key prognostic markers for neuroblastoma patients22. This evidence concerns the gene MYCN and neuroblastoma.