As N-Myc and c-Myc are well known to induce gene transcription by binding to Myc-responsive element E-boxes at target gene promoters23,30, our data suggest that N-Myc and c-Myc overexpression in human neuroblastomas further increases JMJD6 expression, even in JMJD6 gene-gained cells. Here, JMJD6 is linked to neuroblastoma.