In neuroblastoma-bearing mice, THZ1 and panobinostat cooperatively reduce JMJD6 and E2F2 expression, blocks tumor progression, and results in tumor regression, and that forced JMJD6 overexpression in neuroblastoma cells significantly blocks the in vivo anticancer effects of THZ1 and panobinostat combination therapy. This evidence concerns the gene E2F2 and neuroblastoma.