Immunoblot analysis of tumor tissues from the mice showed that THZ1 and panobinostat cooperatively reduced JMJD6 and E2F2 protein expression only in mice xenografted with empty vector SK-N-AS cells, and that transfection with the JMJD6 ORF expression construct led to considerable JMJD6 and E2F2 protein overexpression and nonresponse to THZ1 and panobinostat therapy (Fig. 7f). The gene discussed is E2F2; the disease is neoplasm.