We therefore examined whether N-Myc and c-Myc modulated JMJD6 gene expression in CHP134 (chromosome 17q21-ter/JMJD6 gained and MYCN amplified) and SK-N-AS (chromosome 17q21-ter/JMJD6 gained and MYCN-non-amplified) neuroblastoma cells. The gene discussed is JMJD6; the disease is neuroblastoma.