Importantly, we have confirmed that JMJD6 protein forms a complex with BRD4 protein in neuroblastoma cells, that JMJD6 protein directly binds to N-Myc protein at the Myc Box II region, and that the majority of super-enhancers, typical enhancers, and promoters bound by JMJD6 are also bound by N-Myc. The gene discussed is MYCN; the disease is neuroblastoma.