JMJD6 and neuroblastoma: Importantly, using the median or upper quartile of JMJD6 mRNA expression as the cut-off points, multivariable Cox regression analysis showed that high levels of JMJD6 mRNA expression was associated with poor patient overall survival and event-free survival, independent of disease stage, age at the time of diagnosis and MYCN amplification status (Table 1), and the current key prognostic markers for neuroblastoma patients22.