CRH and post-traumatic stress disorder: We used two distinct stressors in the mouse model, (i) a prenatal stressor in late gestation, CRF-inducedPNS24, a critical time window for stress reactivity with a vast effect on epigenetic programming25,26 and (ii) a mouse model for inducing PTSD in adulthood27, to understand the effect of epigenetic priming when the stress response is activated after early life development.