Peripheral effects of reduced GILZ on increases in inflammation may help explain PTSD and its high comorbidity (up to 19%) with autoimmune diseases53, such as higher levels of circulating IL-6, T-cell lymphocytes, increased prevalence of rheumatoid arthritis, psoriasis, insulin-dependent diabetes, thyroid disease, inflammatory bowel disease, multiple sclerosis, and lupus10. Here, IL6 is linked to rheumatoid arthritis.