CRH and Anxiety: The first assessed the effects of CRF-inducedPNS on anxiety-like behaviors in adulthood and indicated that in a similar manner to that found in adult male mice, CRF-inducedPNS alone, without exposure to any additional stressors, did not affect anxiety-like indices in the open field, dark–light transfer and elevated plus maze tests (Supplementary Fig. 4a–c).