Analysis of T cells (a critical source of type I IFN in this disease) (50, 51) from a cohort of SLE-positive, treatment-naive patients revealed unaltered STING and an elevated level of TMEM203, with a concurrent suppression of MAVS mRNA levels, suggesting that TMEM203 may be an important and previously unrecognized component in the pathology of SLE. Here, MAVS is linked to systemic lupus erythematosus.