Analysis of T cells (a critical source of type I IFN in this disease) (50, 51) from a cohort of SLE-positive, treatment-naive patients revealed unaltered STING and an elevated level of TMEM203, with a concurrent suppression of MAVS mRNA levels, suggesting that TMEM203 may be an important and previously unrecognized component in the pathology of SLE. This evidence concerns the gene TMEM203 and systemic lupus erythematosus.