Constitutively activated STING variants have been found in patients diagnosed with severe symptoms of type I interferonopathy, leading to diseases such as STING-associated vasculopathy with onset in infancy (SAVI) (12), systemic lupus erythematosus (SLE) (5), and familial chilblain lupus (FCL) (13). The gene discussed is STING1; the disease is STING-associated vasculopathy with onset in infancy.