As shown in Table 2, high KRT18 expression associated with clinical stage (P=0.003, Table 2), tumor invasion depth (P=0.009, Table 2), lymph node metastasis (P=0.008, Table 2), distant metastasis (P=0.001, Table 2), and degree of differentiation (P=0.005, Table 2), but had no significant association with gender (P=0.082, Table 2), age (P=0.862, Table 2), family history (P=0.447, Table 2), and location (P=0.083, Table 2). The gene discussed is KRT18; the disease is metastatic malignant neoplasm in the lymph nodes.