Moreover, univariate Cox regression analysis revealed that clinical stage (P=0.004, Table 3), tumor invasion depth (P=0.022, Table 3), lymph node metastasis (P=0.009, Table 3), distant metastasis (P<0.001, Table 3), family history (P=0.042, Table 3), and KRT18 expression (I–IIA vs. IIB–IV, P<0.001, Table 3) were prognostic factors for CRC patients. This evidence concerns the gene KRT18 and neoplasm.