Of these 118 genes, we focused on the Notch1-mediated regulation of Akt/PKB signaling, since alternation of Notch1 has been reported in some ALS models or patients [17, 41, 48], and Akt is tightly involved in the maintenance of synaptic integrity and motor neuron survival [9, 23, 40, 52]. The gene discussed is NOTCH1; the disease is amyotrophic lateral sclerosis.