A recent report based on integrated molecular analysis has proposed that epithelioid GBM should be stratified into three subsets: a PXA subset with a high percentage of BRAF V600E mutations but a relatively low percentage of TERT promoter mutations, an adult IDH-wildtype GBM subset with a relatively low percentage of BRAF V600E mutations but a high percentage of TERT promoter mutations, and a pediatric RTK1 subset not harboring either mutation [34]. This evidence concerns the gene TERT and pleomorphic xanthoastrocytoma.