While Akt SUMOlyation and phosphorylation are both decreased in response to SAE1 suppression on cell lines and glioma mouse models, in which cell cycle arrest and cell apoptosis are obviously changeable because of CDK2, Cyclin D1, Bcl-2 significantly decreased, and p21 and active Caspase-3 increased (Fig. 6). This evidence concerns the gene CASP3 and central nervous system cancer.