In particular, SAE1 was high expression in 69.6% (48/69) human glioma tissues, with an average staining score 7.76 ± 0.32 and other 21 cases (30.4%, 10/69) showed low SAE1 expression with mean staining scores 3.19 ± 0.22. This evidence concerns the gene SAE1 and central nervous system cancer.