CD47 and breast cancer: In the examples shown on breast cancer metastasizing in the bone, the restoration induced by the ordered dynamics strongly affects the extravasating cancer cells because, although the cells with mutation in the CD47 gene are sent to apoptosis by the drug, many other cells which present much less effective driver mutations (in this specific case only one effective driver mutation) survive, and some of these surviving cells are mutationally a few steps away from becoming highly tumorigenic.