Through univariate analysis (UA) and multivariate analysis (MA), we concluded that along with positive lymph node metastasis (P < 0.001 for UA and P = 0.012 for MA), the independent prognostic factors of OS in NSCLC patients may be related to the SETD5 overexpression (P < 0.001 for UA and P = 0.013 for MA, Table 2). Here, SETD5 is linked to non-small cell lung carcinoma.