ESR2 and colorectal cancer: Using the azoxymethane (AOM)/dextran-sulfate-sodium (DSS) animal model, which is widely used to study inflammation-associated colorectal cancer, we recently demonstrated that a diet enriched with phytoestrogens (the flavonolignan silymarin) and anti-inflammatory compounds (boswellic acids) exerts significant chemo-prevention due to inflammation reduction, epithelial turnover/apoptosis increase, and ERβ stimulation [71].