ABCC2 and ovarian carcinoma: However, increased levels and defective glycosylation of MRP family members 1 and 4 in oxaliplatin resistant ovarian cancer cell lines were found to be associated with decreased platinum drug accumulation [50], while Myint et al. [51] observed that l-OHP was a substrate for MRP2 in isolated inverted MRP2 overexpressing vesicles.