In glioblastoma, we identified an RND1low signature of six genes (ITGA5, COL3A1, COL5A1, MET, COL1A2, LAMC1), upregulated in glioblastoma patients with low RND1, that predicts the overall survival of glioblastoma patients. The gene discussed is COL3A1; the disease is glioblastoma.