Two distinct siRNA-SNAPL formulations, the ALN-TTR01 and ALN-TTR02, targeting the TransThyRetin (TTR, TRANsports THYroxine and Retinol) gene encoding for the protein TransThyRetin (TTR), were developed by Alnylam Pharmaceuticals for the cure of amyloid diseases associated with a TTR overexpression. The gene discussed is TTR; the disease is amyloidosis.