TTR and amyloidosis: In particular, ALN-TTR01, in which SNAPL are obtained by the Tekmira technique, and is administered to 32 patients with transthyretin amyloidosis, produced mild-to-moderate infusion-related reactions in 20.8% of patients, and at the highest dose of 1.0 mg/kg, a mean reduction at day seven of 38% for the TTR plasma level.