These changes in the brain activities of Fabp3 null mice are likely to be similar to that observed in subjects with PTSD [33,34,35,36,37,38,39,46,47], and moreover, this is first report to demonstrate the relationship between FABP and PTSD, suggesting that Fabp3 null mice are useful genetic models to study the pathophysiology, and assess the effect of novel candidate drugs on PTSD symptom. Here, FABP3 is linked to post-traumatic stress disorder.