Song and colleagues also found the inhibitory effects of Gaba on the proliferation and metastasis of colon cancer cells (SW480 and SW620 cells) due to the up-pressing cell cycle progression (G2/M or G1/S phase), attenuating mRNA expression of EGR1-NR4A1 and EGR1-Fos axis, and disrupting MEK-EGR1 signaling pathway [80]. Here, EGR1 is linked to colonic neoplasm.