It affects ∼ 3 to 10% of pregnant women, depending on the population studied and on the diagnostic criteria adopted.1, 2 Gestational diabetes mellitus is diagnosed when glucose intolerance, with consequent hyperglycemia, begins or is only identified during pregnancy,3 resulting from the inability of the pancreas to meet the increasing demand for insulin that usually occurs in the 2nd trimester of pregnancy.3, 4 It is known that GDM is a risk condition both for mother and child, with both immediate and long-term possible complications.5 Here, INS is linked to gestational diabetes.