The same comparison between early and established RA (Fig 4B) has no threefold significantly differentially expressed genes, but shows two things: the aforementioned genes for cytoskeleton changes are different between earlyRA and establishedRA, this special difference in men and women is only present at earlyRA (see also S10 Fig for the same comparison between establishedRA and normal condition), and secondly, that some cytokines and the two genes PTGS2 and TFPI2 are stronger expressed in men with established RA. This evidence concerns the gene TFPI2 and rheumatoid arthritis.