This protein plays an indispensable role in the processes of cell growth, proliferation, differentiation, and apoptosis.19, 20, 21 In recent years, several groups reported amplified MYCN gene in different human cancers, such as human neuroblastoma, small cell lung carcinomas, astrocytoma, and retinoblastoma.22, 23 In addition, MYCN copy number increased in 17.5% of basal cell carcinoma patients.24 Despite all these achievements, the implication of MYCN gene in Wilms tumor remains not fully clarified, especially the effects of potentially functional single nucleotide polymorphisms (SNPs). This evidence concerns the gene MYCN and astrocytoma (excluding glioblastoma).