MYCN and neuroblastoma: Moreover, a large number of studies have demonstrated that the MYCN gene is closely related to neuroblastoma.36, 37, 38, 39, 40, 41 A study by Zaatiti et al indicated that neuroblastoma IMR‐32 cell lines had significantly decreased proliferation ability after MYCN knockout.42MYCN not only is related to the development of neuroblastoma, but also is one of the most powerful prognostic markers of neuroblastoma.