The functions of 200 DEGs mainly include keratinization enrichment, phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, collagen catabolic process, small cell lung cancer, negative regulation of blood vessel endothelial cell migration, and chemical signaling pathway, defense in response to virus, cell-cell adhesion, etc. (Fig. 7). Here, AKT1 is linked to small cell lung carcinoma.