The relation between Notch-1 and HTN has been demonstrated in a recent study that Notch-1 increased proliferation of human pulmonary arterial endothelial cells (hPAECs) in pulmonary arterial hypertension and inhibition of Notch signaling could decrease proliferation and migration of hPAECs [16]. The gene discussed is NOTCH1; the disease is pulmonary arterial hypertension.