MALAT1 and hypertensive disorder: In conclusion, our study provides evidence that up-regulated lncRNA MALAT1 was implicated in regulation of HTN, what’s more, down-regulated lncRNA MALAT1 and inhibited Notch-1 could improve endothelial function, reduced mRNA expression of relative factors, including inflammation-related factors, endothelial function-related factors and oxidative stress-related factors of rats with HTN and restrained apoptosis of aortic endothelial cells, which provided a novel way of HTN therapy.