No significant difference was found of SBP, DBP and MAP among the AngII group, AngII + si-Con group and AngII + DMSO group (Figure 3A–3C, all P > 0.05), suggesting that down-regulated MALAT1 and inhibited Notch-1 could decrease blood pressure level of HTN rats. The gene discussed is NOTCH1; the disease is hypertensive disorder.