NOTCH1 and hypertensive disorder: In order to investigate the effects of repressed MALAT1 and inhibited Notch-1 signaling pathway on the blood pressure level of HTN rats, the blood pressure of rats in each group was determined by a tail-artery blood pressure-measuring instrument, the results unraveled that the levels of SBP, DBP and MAP of rats in the AngII group significantly increased compared with the Con group (all P < 0.05).