To observe the impacts of down-regulated MALAT1 and inhibited Notch-1 signaling pathway on apoptosis of aortic endothelial cells of HTN rats, TUNEL staining was employed to assess the apoptosis of aortic endothelial cells of HTN rats, and the results indicated that the apoptosis index of endothelial cells of rats in the AngII group increased compared with the Con group (P < 0.05). The gene discussed is MALAT1; the disease is hypertensive disorder.