After the HTN rats were treated with down-regulated MALAT1 vector and Notch pathway inhibitor (DAPT), the changes of expression of lncRNA MALAT1 and Notch-1 in rat’s vascular tissues were measured by RT-qPCR and western blot analysis, the results indicated that the lncRNA MALAT1 and Notch-1 expression in the AngII group was up-regulated compared with the Con group (P < 0.05), expressed for the high expression of lncRNA MALAT1 and Notch-1 in HTN vascular tissues. This evidence concerns the gene AGT and hypertensive disorder.