There was no significant difference of protein expression of Bax and Bcl-2 among the AngII group, AngII + si-Con group and AngII + DMSO group (Figure 9C–9D, P > 0.05), suggesting that down-regulated MALAT1 and inhibited Notch-1 signaling pathway could decelerate apoptosis of aortic endothelial cells of HTN rats. The gene discussed is NOTCH1; the disease is hypertensive disorder.