However, the relation among MALAT1, Notch-1 and HTN has not been studied yet, hence, this study was conducted to focus on the capacity of MALAT1 and Notch-1 in HTN, and we speculated that down-regulated lncRNA MALAT1 could alleviate the vascular lesion and remodeling of HTN rats, the mechanism may be related to the inactivation of Notch signaling pathway. The gene discussed is NOTCH1; the disease is hypertensive disorder.