There was no obvious difference of collagen-I, collagen-III and Fibronectin expression among the AngII group, AngII + si-Con group and AngII + DMSO group (Figure 8B–8D, all P > 0.05), indicating that down-regulated MALAT1 and inhibited Notch-1 signaling pathway could alleviate vascular fibrosis of thoracic aorta of HTN rats. The gene discussed is NOTCH1; the disease is hypertensive disorder.