Masson staining was adopted in order to investigate the effects of down-regulated MALAT1 and inhibited Notch-1 on vascular fibrosis of thoracic aorta of HTN rats, the result of Masson staining suggested that there was obvious and complete structure of thoracic aorta, slender and uniform distribution in the rats of the Con group. The gene discussed is NOTCH1; the disease is hypertensive disorder.