RUNX1 and Ehlers-Danlos syndrome: Other examples of Runx1-target genes that may be potentially vasculature-relevant are extracellular matrix molecules such as fibronectin (Lee et al., 2014), a gene with known functions in vasculature development and cancer (Kostourou and Papalazarou, 2014), or Colagen 5a1 implicated in familial Ehlers-Danlos syndrome with lethal arterial events (Monroe et al., 2015).