While our analyses provide evidence that the emphysema-associated GWAS region downstream from TGFB2 interacts with the promoter of TGFB2 and regulates the expression of TGFB2 in human primary lung fibroblasts, many important questions remain about the function of the emphysema-associated locus near TGFB2. First, the rs1690789 variant appears to be an eQTL for expression of TGFB2 in fibroblasts, but it is also strongly associated with TGFB2 expression in thyroid tissue in GTEx with an opposite direction of effect, suggesting complex and possibly context-dependent activity of this region. The gene discussed is TGFB2; the disease is pulmonary emphysema.