In summary, integrative GWAS-eQTL analysis of emphysema patterns identified 32 candidate loci with strong evidence of harboring gene regulatory variants responsible for the GWAS signal, including a locus near TGFB2. Functional investigation of the associated region near TGFB2 confirmed the presence of a functional variant, rs1690789, that likely contributes to the genetic predisposition to emphysema by regulating TGFB2 expression in fibroblasts. This evidence concerns the gene TGFB2 and pulmonary emphysema.