PKM2 is normally present in the cytoplasm by a form of homotetramer and functions as a metabolic kinase with high catalytic activity.8 In addition, a dimeric PKM2 form has been recently confirmed in cell nucleus, while it works as a protein kinase stimulating transcription to regulate the growth, survival and metastasis of tumour cells.8, 28 In our study, we discovered that β‐elemene suppressed PKM2 translocating into the nucleus. This evidence concerns the gene WEE1 and neoplasm.