But in other tissues, the TNF‐a‐related NF‐kB and WNT signalling pathways were always competing.35, 36 Especially in bone, TNF‐a took the regulation of Semaphorin3B from WNT signalling pathway, which ultimately induced osteoporosis.37 The effects of the NF‐kB and WNT signalling pathways interactions are likely to depend on the specific cell or tissue type. Here, TNF is linked to osteoporosis.