Consistent with the behavioral andneuronal effects observed in Tlr4−/− male mice,pharmacological inhibition of TLR4 function using TAK-242 antagonistsignificantly attenuated the 48/80-induced photophobia and p-ERK activation.In the following sections, we will review several issues pertinent to theinterpretation of these migraine data sets. The gene discussed is TLR4; the disease is migraine disorder.