But, CHRNA3 (OMIM#118503) polymorphisms were found to contribute to an increased risk of lung cancer in the Han individuals who smoke (Zhou et al., 2015), however, CHRNA3 variant (rs8042374, NM_000743.4:g.78615690A>G) was linked to a greater risk of lung adenocarcinoma in female nonsmokers (He et al., 2014). The gene discussed is CHRNA3; the disease is lung cancer.