Its original name was IL‐10‐related T cell–derived inducible factor (IL‐TIF), and it was discovered in 2000 as a new member of the IL‐10 family of cytokines.23 Various types of cells produce IL‐22, including Th17, Th22, and NK cells, and group 3 innate lymphoid cells (ILC3s).24, 25, 26, 27 Recently, increasing evidence has indicated that IL‐22 plays diverse roles in the pathogenesis of autoimmune diseases, including pathogenic and protective processes. This evidence concerns the gene IL10 and autoimmune disease.