In systemic lupus erythaematosus (SLE), decreased plasma IL‐22 levels are correlated with SLE disease activity and could result in the rs2227513 polymorphism, which might contribute to SLE susceptibility.12, 13 In contrast, the Yang14 group showed that IL‐22 levels in both the serum and the kidneys were significantly higher in lupus nephritis (LN) patients than in healthy controls. This evidence concerns the gene IL22 and lobular neoplasia.