LEP and obesity due to melanocortin 4 receptor deficiency: 2018), the distinct leptin sensitivity patterns in LS versus LR rats were not associated with differences in body weight, caloric intake, and adiposity on a chow diet (Fig. S1). The increased susceptibility for the development of obesity in LR rats was previously specifically shown after exposure to an obesogenic fcHFHS diet (de Git et al. 2018).