Insulin signalling in skeletal muscle or adipose tissue was not affected in either model.131 In another study, mutated form of SHIP2 lacking the 5′‐phosphatase activity was introduced via adenoviral infection into KKAy mice, a model of hyperglycemia and hyperinsulinemia.132 This resulted in increased basal and insulin‐stimulated Akt activation in liver, decreased glucose production after puryvate challenge, and increased hepatic glycogen content. This evidence concerns the gene INS and Hyperinsulinemia.