A study with Finnish patients with T1D identified an association of two SNPs in INPPL1 with the metabolic syndrome in men,123 and another study on British patients with T2D found an association of SNPs and haplotypes of INPPL1 with hypertension and other components of the metabolic syndrome.124 The metabolic effects of the mutations and single nucleotide polymorphisms in INPPL1 are summarized in Table 1. Here, INPPL1 is linked to type 2 diabetes mellitus.