The first model targeted exons 19‐29 of Inppl1 (mouse SHIP2 gene).127 The mice showed increased sensitivity to insulin and reduced expression of hepatic gluconeogenic enzymes, leading to neonatal hypoglycemia and death within 3 days after birth.127 Compared to the wild type mice, the adult heterozygous mice showed greater insulin sensitivity, higher expression of GLUT4 at the plasma membrane, and responded to insulin stimulation with higher glycogen synthesis rate in the skeletal muscle. This evidence concerns the gene INS and Hypoglycemia.