INPPL1 and neurodegenerative disease: Mutations in INPPL1 (gene encoding SHIP2) have been revealed in opsismodysplasia, a disease of bone maturation,116, 117 and via its various activities, SHIP2 associates with many other diseases, including diabetes, cancer, atherosclerosis and neurodegenerative diseases (for reviews, see, for example 108, 118, 119).