INPPL1 and diabetic kidney disease: As described in the above paragraph, the effects of SHIP2 inhibition on metabolic parameters in vitro and in vivo point out a clear beneficial role for SHIP2 inhibition in reducing insulin resistance and hyperglycemia and improving glucose metabolism.139, 140, 141, 142 In addition, SHIP2 inhibition by metformin protects podocytes from injury at a stage when SHIP2 expression or activity is elevated, such as in DKD,140 proposing that SHIP2 inhibition could be a potent approach to prevent DKD.