Beneficial effects of SHIP2 inhibition have been proposed in breast135, 177 and colorectal cancer.136 In gastric cancer specimens, however, SHIP2 expression is frequently downregulated, and this enhances the malignant behaviour of gastric cancer cells.178 Accordingly, it appears that the effects of SHIP2 in different cells are context dependent. Here, INPPL1 is linked to colorectal cancer.