AKT1 and cancer: In the case of SHIP2, its hydrolysis product, PtdIns(3,4)P2, binds to Akt more potently than PtdIns(3,4,5)P3.170 Furthermore, both PtdIns(3,4)P2 and PtdIns(3,4,5)P3 are required for the high‐level activation of Akt.171 It has been proposed that both PtdIns(3,4)P2 and PtdIns(3,4,5)P3 are necessary for cancer cell survival and malignancy, and both their absolute amount and ratio control cell death.172 In line with this “two PIP hypothesis”, studies revealing SHIP2 as a target to treat cancer and showing beneficial effects of SHIP2 inhibitors are emerging.