A number of studies have demonstrated the function that HSPA5 plays in cancer metastasis and in anti‐apoptotic process of cancer cells.25 HSPA5 expression positively correlates with the large tumour size, aggressiveness, high clinical stage and resistance to conventional chemotherapy of RCC.26 Additionally, several studies have focused on the regulation mechanism or signalling pathway of the differential expression of HSPA5 in cancers. This evidence concerns the gene HSPA5 and cancer.