BRCA1 and breast carcinoma: The National Cancer Institute estimates for 2018 were that more than 266,000 new cases of invasive breast cancer would be diagnosed in the United States, and more than 40,000 patients would die from the disease.2 Approximately 10% of breast cancers are associated with a pathogenic germline variant in one of several different genes.3 More than 50% of pathogenic germline variants are mutations in the BRCA1 and BRCA2 genes.4–9 Using genetic testing to identify patients who are at increased risk to develop breast cancer enables patients to take steps to reduce this risk.