Melanocytes escape keratinocyte-regulated growth control by downregulating adhesion molecules such as E-cadherin (Haass et al. 2005), increasing melanoma-to-melanoma and melanoma-to-fibroblast cell adhesion molecule, N-cadherin and loss of cell anchorage due to changes in expression of integrin protein family members (Haass et al. 2005; Jamal and Schneider 2002). The gene discussed is CDH1; the disease is melanoma.