We have noted significantly increased IL-6 serum levels in BCC patients in comparison with healthy controls (median 3.44; mean 5.59 ± 10.02 pg/ml; range 0.61–101.00 pg/ml vs. median 1.05; mean 1.39 ± 1.28 pg/ml; range 0.08–6.27 pg/ml; p < 0.00001). This evidence concerns the gene IL6 and skin basal cell carcinoma.