In canine OS, these same genes and pathways have been shown to be commonly altered, while somatic mutations in the histone methyltransferase SETD2, and germline variants in the cyclin-dependent kinase inhibitor CDKN2A/B were recently identified in tumor samples from Rottweilers, Greyhounds and Golden Retrievers14. The gene discussed is PRDM9; the disease is neoplasm.