CASP12 and neoplasm: When all genes were considered together, a cluster of 31 genes involved in aspects of immune response was shown to be underexpressed among most of the tumor samples (Supplementary Data 14 and 15) including those involved in chemokine and cytokine signaling (chemokine receptors-2 and -5, interleukin-31 receptor A, toll-like receptor 7), complement activation (complement C1q B-chain, complement C3a receptor 1, complement factor properdin) and caspase-mediated apoptosis (caspase-12, caspase recruitment domain family member-11).