TEFM and neoplasm: We also noted that SMU1, NOL6, RPS6, and WAPAL are completely conserved against germline loss-of-function mutations in the GNOMAD database39 (pLI > 0.98), and TEFM and COPRS partly conserved (pLI = 0.51 and 0.25, respectively), though it is not given that a gene that is conserved against heterozygous loss-of-function variants in the germline (which is mainly what the pLI score reflects) is essential for the survival of tumor cells, or vice versa.