In the present study, we found that XJEK significantly (1) suppressed the cardiovascular remodeling and ECG remodeling and improved cardiac function abnormalities in a rat model of MI for 2, 4 and 6wk; (2) alleviated the increasing levels of ET-1, ETA and Ang II of each time point; (3) inhibited the reduction of NO, BH4 content and eNOS dimer/ (dimer+monomer) ratio therefore ameliorated ED. Here, EDN1 is linked to myocardial infarction.