Compared with the corresponding sham groups, the ET-1 levels in serum (2 wk, 6 wk P<0.01 and 4 wk P<0.05) and cardiac tissues (2, 4, and 6 wk P<0.05) were upregulated continuously in MI groups for 2, 4, and 6 wk (Figures 9(a) and 9(b)). This evidence concerns the gene EDN1 and myocardial infarction.