AKT1 and colorectal cancer: The upregulated DEGs were significantly enriched in five KEGG pathways, including ECM-receptor interaction, focal adhesion, and PI3K-Akt signalling pathway, while the downregulated DEGs were significantly enriched in MAPK signalling pathway, PI3K-Akt signalling pathway, osteoclast differentiation, and colorectal cancer (Figure 3(c)).