To date, a partial understanding has gained about the complex mechanisms that how TGF-β signaling is constitutive in EMT [63], the most well-known mechanism is that Smad-mediated transcription regulation is activated in TGF-β induced EMT [64, 65], and attenuating TGF-β signaling pathways has been the main strategy to withstand cancer associate fibrosis [66]. Here, TGFB1 is linked to cancer.