In our population, we found through the regression analysis that hypohidrosis, reduced αGal-A activity, angiokeratomas, male gender, neuropathic pain, hearing loss, cardiac involvement, and renin-angiotensin-aldosterone system (RAAS) inhibitors treatment are clinical variables associated with urinary microRNAs excretion profile indicative of renal fibrosis. This evidence concerns the gene REN and renal fibrosis.