One strategy for building a universal influenza vaccine focuses on targeting highly conserved surface epitopes shared by different strains of virus.36,37 An epitope recognized by several broadly neutralizing mAbs (e.g., CR9114) includes HxA, the first alpha helical domain within the HA stalk.27,28 Here we successfully recreated the secondary structure of the HxA epitope by appending the linear HxA H1N1 sequence on the helical N-terminus of the carrier. The gene discussed is AMY2B; the disease is influenza.