IGHE and allergic asthma: The first monoclonal Ab (mAb) approved for allergic asthma, omalizumab, recognizes a linear epitope on the Cε3 loop within the IgE heavy chain and prevents IgE receptor activation.25,26 P10 peptide synthesized with the murine homolog of omalizumab’s epitope (DHPDFPKPIV)18,26 at its C-terminus exhibited an average DLS diameter of ~15 nm (Supplementary Fig. 5).