In several studies determined that Azurin and its derivative can attach to merozoite surface protein 1 (MSP1) of Plasmodium falciparum, gp120 of HIV-1, parasite surface antigen SAG1 of Toxoplasma gondii, dendritic cell-specific adhesion receptor (DC-SIGN) and intercellular adhesion molecule ICAM-3 then considerably decrease parasitemia, parasite invasion and HIV growth (12, 13). This evidence concerns the gene ITIH4 and parasitic infectious disease.