SLC2A2 and obesity due to melanocortin 4 receptor deficiency: The supplementation of MG to the HF diet caused a further decrease in phosphorylated/total insulin receptor ratio and inhibited GLUT2 increase, showing that glycation-driven changes in the liver lipidemic profile are associated with impaired insulin receptor signaling and contributes to insulin resistance in obesity (Figures 5(e) and 5(f)).