The supplementation of MG to the HF diet caused a further decrease in phosphorylated/total insulin receptor ratio and inhibited GLUT2 increase, showing that glycation-driven changes in the liver lipidemic profile are associated with impaired insulin receptor signaling and contributes to insulin resistance in obesity (Figures 5(e) and 5(f)). Here, INSR is linked to obesity due to melanocortin 4 receptor deficiency.