Clinical multi-gene hereditary ovarian cancer (OC) panels include genes that function in the same homologous recombination (HR) DNA repair pathway as BRCA1 and BRCA2, such as ATM, BARD1, BRIP1, CHEK2, NBN, PALB2, RAD51C, and RAD51D. These genes have been linked to hereditary ovarian cancer, but the extent to which some of these genes contribute to hereditary OC varies in the literature [1–7]. The gene discussed is CHEK2; the disease is familial ovarian cancer.